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Details on Person TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK

Class:Id	BlackBoxEvent:5668414
_displayName	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
_doRelease	TRUE
_timestamp	2015-05-25 03:50:51
authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
catalystActivity	[CatalystActivity:5668451] transferase activity of Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643362] transferase activity of Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] Self-termination of the terminator
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
input	[Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [DefinedSet:5676554] Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5668419] Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK [LiteratureReference:5668503] Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
modified	[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26 [InstanceEdit:5668904] Garapati, Phani Vijay, 2015-01-29 [InstanceEdit:5676588] Garapati, Phani Vijay, 2015-02-20 [InstanceEdit:5692512] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
output	[Complex:5668433] TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer [Homo sapiens] [Reaction:5668467] 2xTNFR2 binds TNFA trimer:TNFR2 [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695850] R-HSA-5668414.3
summation	[Summation:5668492] Following recruitment to receptor, TRAF2 mediates K63-linked...
(hasEvent)	[Pathway:5668541] TNFR2 non-canonical NF-kB pathway [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 [Homo sapiens]
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