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Details on Person SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it

Class:Id	BlackBoxEvent:5666049
_displayName	SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it
_doRelease	TRUE
_timestamp	2015-03-04 04:14:17
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:5666048] Orlic-Milacic, Marija, 2015-01-20
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[EntityWithAccessionedSequence:5666054] ITGB1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5666004] SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
modified	[InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674560] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it
output	[EntityWithAccessionedSequence:57596] ITGB1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5666046] SRF:MKL1 binds ITGB1 Gene [Homo sapiens] [Reaction:5665998] MKL1 binds SRF [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:5666047] Negative gene expression regulation by 'SRF:MKL1:SCAI [nucleoplasm]' [PositiveGeneExpressionRegulation:5666053] Positive gene expression regulation by 'SRF:MKL1:ITGB1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641708] Negative gene expression regulation by 'SRF:MKL1:SCAI [nucleoplasm]' SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin [RegulationReference:9643016] Positive gene expression regulation by 'SRF:MKL1:ITGB1 Gene [nucleoplasm]' SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680225] R-HSA-5666049.4
summation	[Summation:5666045] SRF:MKL1 binding to the promoter region of the integrin beta...
(hasEvent)	[Pathway:5663220] RHO GTPases Activate Formins [Homo sapiens]
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No pathways have been reviewed or authored by SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (5666049)