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Details on Person SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments

Class:Id	Reaction:5665809
_displayName	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
_doRelease	TRUE
_timestamp	2015-03-04 04:21:47
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5665807] GTPase activity of SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5665808] Orlic-Milacic, Marija, 2015-01-19
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[Complex:5665803] SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5665805] Bi-modal regulation of a formin by srGAP2
modified	[InstanceEdit:5665813] Orlic-Milacic, Marija, 2015-01-19 [InstanceEdit:5665964] Orlic-Milacic, Marija, 2015-01-20 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674560] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
output	[EntityWithAccessionedSequence:195131] SRGAP2 [cytosol] [Homo sapiens] [Complex:445010] RAC1:GDP [cytosol] [Homo sapiens] [Complex:203080] Profilin:G-actin [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] [Complex:5665949] FMNL1 [cytosol] [Homo sapiens] [Complex:203080] Profilin:G-actin [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5665802] SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin [Homo sapiens] [Reaction:5665659] RAC1:GTP:FMNL1 binds profilin:G-actin [Homo sapiens]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680358] R-HSA-5665809.2
summation	[Summation:5665812] SRGAP2 is a GTPase activating protein that stimulates the GT...
(hasEvent)	[Pathway:5663220] RHO GTPases Activate Formins [Homo sapiens]
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No pathways have been reviewed or authored by SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (5665809)