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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of RHO GTPases Activate Formins

Class:IdPathwayDiagram:5665637
_displayNameDiagram of RHO GTPases Activate Formins
_timestamp2017-03-18 02:34:14
created[InstanceEdit:5665639] Orlic-Milacic, Marija, 2015-01-19
height975
modified[InstanceEdit:5665650] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665651] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665677] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665737] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665739] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665754] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665755] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665764] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665774] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665798] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665806] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665810] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665813] Orlic-Milacic, Marija, 2015-01-19
[InstanceEdit:5665964] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5665965] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5665996] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5666003] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5666014] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5666055] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5666056] Orlic-Milacic, Marija, 2015-01-20
[InstanceEdit:5666060] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666084] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666097] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666107] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666155] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666163] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666168] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666172] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:5666173] Orlic-Milacic, Marija, 2015-01-21
[InstanceEdit:8982504] Orlic-Milacic, Marija, 2017-03-18
representedPathway[Pathway:5663220] RHO GTPases Activate Formins [Homo sapiens]
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binds RAC1:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="126" reactomeId="5665659" points="373 120, 376 96, 440 65" position="376 96" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="127" stoichiometry="2" points="378 214" /> <Input id="17" points="333 68" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Properties> <displayName>RAC1:GTP:FMNL1 binds profilin:G-actin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="203070" points="379 291, 378 292, 378 242" position="378 292" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="154" points="346 303" /> <Input id="155" points="342 282" /> </Inputs> <Outputs> <Output id="127" /> </Outputs> <Properties> <displayName>Association of profilin with monomeric actin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="408" reactomeId="5665686" points="122 153, 135 172, 154 190" position="135 172" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="413" points="78 240" /> <Input id="1108" points="202 169" /> </Inputs> <Outputs> <Output id="410" /> </Outputs> <Properties> <displayName>FMNL1 binds CDC42:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="411" reactomeId="5665727" points="114 325, 126 306, 161 291" position="126 306" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="413" points="79 268" /> <Input id="1133" points="212 328" /> </Inputs> <Outputs> <Output id="414" /> </Outputs> <Properties> <displayName>FMNL2 binds CDC42:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="563" reactomeId="5665748" points="112 355, 124 365, 144 374" position="124 365" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="564" points="89 410" /> <Input id="1133" points="212 335" /> </Inputs> <Outputs> <Output id="565" /> </Outputs> <Properties> <displayName>FMNL2 binds RHOC:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="602" reactomeId="5665751" points="343 187, 363 181, 459 118" position="363 181" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="127" stoichiometry="2" points="369 214" /> <Input id="414" points="232 247" /> </Inputs> <Outputs> <Output id="603" /> </Outputs> <Properties> <displayName>CDC42:GTP:FMNL2 binds Profilin:G-actin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="716" reactomeId="5665761" points="178 434, 177 445, 177 480" position="177 445" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="564" points="124 427" /> <Input id="1206" points="242 427" /> </Inputs> <Outputs> <Output id="718" /> </Outputs> <Properties> <displayName>FMNL3 binds RHOC:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="805" reactomeId="5665767" points="480 370, 479 370, 515 166" position="479 370" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="127" stoichiometry="2" points="386 242" /> <Input id="718" points="216 480" /> </Inputs> <Outputs> <Output id="806" /> </Outputs> <Properties> <displayName>Activated FMNL3 binds G-actin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1039" reactomeId="5665802" points="573 76, 601 84, 632 82" position="601 84" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1040" points="599 194" /> <Input id="128" points="530 65" /> </Inputs> <Outputs> <Output id="1041" /> </Outputs> <Properties> <displayName>SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1104" reactomeId="5665809" points="686 166, 686 196, 661 215" position="686 196" lineWidth="1.0"> <Inputs> <Input id="1105" points="668 167" /> <Input id="1041" points="689 111" /> </Inputs> <Outputs> <Output id="127" stoichiometry="2" points="430 238, 521 260" /> <Output id="1108" points="202 164, 78 110, 77 11, 765 12, 756 200" /> <Output id="1107" points="637 290" /> <Output id="1040" points="634 211" /> <Output id="1106" points="818 147, 796 227" /> </Outputs> <Catalysts> <Catalyst id="1041" points="702 111, 729 167" /> </Catalysts> <Properties> <displayName>SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1463" reactomeId="5665989" points="237 566, 234 582, 206 597" position="234 582" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1464" points="209 566" /> <Input id="1465" points="246 544" /> </Inputs> <Outputs> <Output id="1466" /> </Outputs> <Properties> <displayName>DIAPH1 binds RHOA:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1541" reactomeId="5665982" points="323 612, 323 612, 351 614" position="323 612" lineWidth="1.0"> <Inputs> <Input id="1542" points="315 576" /> <Input id="1543" stoichiometry="2" points="372 510" /> <Input id="1466" points="222 616" /> </Inputs> <Outputs> <Output id="1544" stoichiometry="2" points="407 600" /> <Output id="1545" points="220 669, 348 665" /> </Outputs> <Properties> <displayName>RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1582" reactomeId="5666001" points="466 456, 467 455, 401 482" position="467 455" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="127" points="383 242" /> <Input id="1544" points="432 582" /> </Inputs> <Outputs> <Output id="1543" /> </Outputs> <Properties> <displayName>Profilin:G-actin binds MKL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1632" reactomeId="5665999" points="454 594, 516 591, 639 588" position="516 591" lineWidth="1.0"> <Inputs> <Input id="1544" /> </Inputs> <Outputs> <Output id="1659" /> </Outputs> <Properties> <displayName>MKL1 translocates from cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1684" reactomeId="5665998" points="712 569, 714 587, 718 612" position="714 587" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1685" points="716 550" /> <Input id="1659" points="687 579" /> </Inputs> <Outputs> <Output id="1686" /> </Outputs> <Properties> <displayName>MKL1 binds SRF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1737" reactomeId="5666008" points="791 614, 803 616, 836 620" position="803 616" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1686" points="756 620" /> <Input id="1738" points="791 573" /> </Inputs> <Outputs> <Output id="1739" /> </Outputs> <Properties> <displayName>SCAI binds SRF:MKL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1965" reactomeId="5666046" points="755 653, 772 657, 789 676" position="772 657" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1686" points="734 640" /> <Input id="1966" points="728 662" /> </Inputs> <Outputs> <Output id="1967" /> </Outputs> <Properties> <displayName>SRF:MKL1 binds ITGB1 Gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2042" reactomeId="5666049" points="728 662, 730 737, 730 829" position="730 737" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1966" /> </Inputs> <Outputs> <Output id="2043" /> </Outputs> <Inhibitors> <Inhibitor id="1739" points="872 646, 869 770" /> </Inhibitors> <Activators> <Activator id="1967" points="770 718" /> </Activators> <Properties> <displayName>SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2058" interactionType="Activate" points="709 866, 670 890" position="689 878" lineWidth="2.0"> <Inputs> <Input id="2043" /> </Inputs> <Outputs> <Output id="2056" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2059" interactionType="Activate" points="756 866, 793 884" position="774 875" lineWidth="2.0"> <Inputs> <Input id="2043" /> </Inputs> <Outputs> <Output id="2057" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2146" reactomeId="5666070" points="326 704, 332 731, 357 737" position="332 731" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2147" points="368 700" /> <Input id="2148" points="313 703" /> </Inputs> <Outputs> <Output id="2150" /> </Outputs> <Properties> <displayName>RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2149" points="252 544, 273 681" position="262 612" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1465" /> </Inputs> <Outputs> <Output id="2148" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2239" reactomeId="5666088" points="373 835, 400 838, 449 827" position="400 838" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2240" points="340 825" /> <Input id="2241" points="386 821" /> </Inputs> <Outputs> <Output id="2242" /> </Outputs> <Properties> <displayName>RHOD:GTP recruits DAIPH2-3 to endosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2305" reactomeId="5666104" points="516 785, 518 770, 523 742" position="518 770" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2306" points="546 778" /> <Input id="2242" points="504 799" /> </Inputs> <Outputs> <Output id="2307" /> </Outputs> <Properties> <displayName>RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2430" reactomeId="5666129" points="596 395, 616 395, 646 383" position="616 395" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2431" points="573 363" /> <Input id="2432" points="608 424" /> <Input id="2556" points="577 394" /> </Inputs> <Outputs> <Output id="2434" /> </Outputs> <Properties> <displayName>CDC42:GTP recruits DIAPH2-2 to kinetochores</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2682" reactomeId="5666160" points="775 369, 793 370, 818 369" position="793 370" lineWidth="1.0"> <Inputs> <Input id="2434" points="742 368" /> <Input id="2683" points="766 341" /> </Inputs> <Outputs> <Output id="2684" points="836 333" /> <Output id="2685" points="863 365" /> </Outputs> <Catalysts> <Catalyst id="2434" points="742 384, 775 397" /> </Catalysts> <Properties> <displayName>AURKB phosphorylates DIAPH2-2 at kinetochores</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2859" reactomeId="5666169" points="711 424, 751 430, 806 444" position="751 430" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2432" points="658 432" /> <Input id="2907" stoichiometry="15" points="688 471" /> </Inputs> <Outputs> <Output id="2621" /> </Outputs> <Activators> <Activator id="2685" points="863 382" /> </Activators> <Properties> <displayName>Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2899" reactomeId="3858495" points="1020 246, 1019 278, 1023 310" position="1020 246" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2900" points="992 249" /> <Input id="2901" points="1021 228" /> </Inputs> <Outputs> <Output id="2902" /> </Outputs> <Properties> <displayName>DAAM1 recruits GTP-bound RHOA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2903" reactomeId="3858489" points="914 210, 921 221, 934 241" position="921 221" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2904" points="892 206" /> <Input id="2905" points="921 191" /> </Inputs> <Outputs> <Output id="2900" /> </Outputs> <Properties> <displayName>ppDVL binds DAAM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2906" interactionType="Activate" points="1027 351, 1031 396" position="1029 373" lineWidth="2.0"> <Inputs> <Input id="2902" /> </Inputs> <Outputs> <Output id="2898" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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