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Details on Person UniProt:Q92743 HTRA1
| Class:Id | ReferenceGeneProduct:56654 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-480 added on Fri February 6 2015 |
| _displayName | UniProt:Q92743 HTRA1 |
| _timestamp | 2026-02-20 21:30:47 |
| chain | signal peptide:1-22 chain:23-480 |
| checksum | CA20A99480FB2330 |
| comment | FUNCTION Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.SUBUNIT Forms homotrimers. In the presence of substrate, may form higher-order multimers in a PDZ-independent manner. Interacts with TGF-beta family members, including BMP4, TGFB1, TGFB2, activin A and GDF5 (By similarity).INTERACTION Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635).TISSUE SPECIFICITY Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).DEVELOPMENTAL STAGE In the placenta, in the first trimester of gestation, low expression in the cells surrounding villi both in the inner layer of the cytotrophoblast and in the outer layer of the syncytiotrophoblast (at protein level). In the third trimester of gestation, very strong expression in the outer layer forming the syncytiotrophoblast and lower in the cytotrophoblast (at protein level).DOMAIN The IGFBP N-terminal domain mediates interaction with TSC2 substrate.DISEASE A variant in the HTRA1 promoter may be associated with increased risk for developing age-related macular degeneration (ARMD), a multifactorial eye disease and common cause of vision loss.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1C family. |
| description | recommendedName: Serine protease HTRA1 ecNumber: 3.4.21.- alternativeName: High-temperature requirement A serine peptidase 1 alternativeName: L56 alternativeName: Serine protease 11 |
| geneName | HTRA1 HTRA PRSS11 |
| identifier | Q92743 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Age-related macular degeneration Cell membrane Cytoplasm Direct protein sequencing Disease variant Disulfide bond Growth factor binding Hydrolase Membrane Protease Proteomics identification Reference proteome Secreted Serine protease Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | HTRA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987874] ENSEMBL:ENSG00000166033 HTRA1 [Homo sapiens] |
| secondaryIdentifier | HTRA1_HUMAN D3DRE4 Q9UNS5 |
| sequenceLength | 480 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8855820] HTRA1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92743 HTRA1 (56654)
