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Details on Person NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors

Class:Id	Reaction:5663271
_displayName	NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors
_doRelease	TRUE
_timestamp	2025-02-18 21:05:14
authored	[InstanceEdit:5663195] May, Bruce, 2015-01-15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5663250] May, Bruce, 2015-01-16
edited	[InstanceEdit:5663195] May, Bruce, 2015-01-15
input	[EntityWithAccessionedSequence:375499] NR1D1 [nucleoplasm] [Homo sapiens] [SimpleEntity:1368125] ferriheme b [nucleoplasm] [EntityWithAccessionedSequence:442464] HDAC3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:442501] NCOR1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5640211] CLOCK gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1368179] Direct regulation of CLOCK expression by REV-ERB
modified	[InstanceEdit:5663310] May, Bruce, 2015-01-17 [InstanceEdit:5663311] May, Bruce, 2015-01-17 [InstanceEdit:9713328] Stephan, Ralf, 2021-01-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors
output	[Complex:5663248] NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) [Homo sapiens] [Reaction:9923010] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:2084235] Delaunay, F, 2012-01-28 [InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679884] R-HSA-5663271.4
summation	[Summation:5663307] NR1D1 (REV-ERBA) binds the promoter of the CLOCK gene and re...
(hasEvent)	[Pathway:9707616] Heme signaling [Homo sapiens] [Pathway:9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 [Homo sapiens]
(replacementInstances)	[_Deleted:9032440] Deletion of instance: 5334727
(updatedInstance)	[_UpdateTracker:9939695] Update Tracker - [Reaction:5663271] NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors - v92:[modifyText]
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