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Details on Person The last stage of pheomelanogenesis is the oxidative polymer...

Class:IdSummation:5662898
_displayNameThe last stage of pheomelanogenesis is the oxidative polymer...
_timestamp2015-01-14 16:35:53
created[InstanceEdit:5662886] Jupe, Steve, 2015-01-14
literatureReference[LiteratureReference:5662905] Metal ions as potential regulatory factors in the biosynthesis of red hair pigments: a new benzothiazole intermediate in the iron or copper assisted oxidation of 5-S-cysteinyldopa
[LiteratureReference:5662881] Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure
[LiteratureReference:5662911] The "benzothiazine" chromophore of pheomelanins: a reassessment
[LiteratureReference:5662954] Zinc-catalyzed oxidation of 5-S-cysteinyldopa to 2,2'-bi(2H-1,4-benzothiazine): tracking the biosynthetic pathway of trichochromes, the characteristic pigments of red hair
modified[InstanceEdit:5662944] Jupe, Steve, 2015-01-14
textThe last stage of pheomelanogenesis is the oxidative polymerization of BT, BTCA, and the products of secondary modifications of the benzothiazine moieties of these to form pheomelanin. Several dimeric and trimeric intermediates have been identified (Napolitano et al. 2001) but it is unclear whether these are major components of natural pheomelanin pigments. Most studies have used powerful chemical oxidants (Di Donato et al. 2002, Napolitano et al. 2008). which may lead to a pheomelanogenesis process that differs from the in vivo process (Wakamatsu et al. 2008).
(summation)[BlackBoxEvent:5662891] pheomelanin formation [Homo sapiens]
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