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Details on Person Defective DCXR does not reduce L-xylulose to xylitol

Class:Id	FailedReaction:5662851
_displayName	Defective DCXR does not reduce L-xylulose to xylitol
_doRelease	TRUE
_timestamp	2015-09-04 20:51:19
authored	[InstanceEdit:5678684] D'Eustachio, Peter, 2015-02-25
catalystActivity	[CatalystActivity:9631949] L-xylulose reductase (NADPH) activity of DCXR H195Tfs*7 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5662852] D'Eustachio, Peter, 2015-01-13
disease	[Disease:5656463] carbohydrate metabolic disorder
edited	[InstanceEdit:5678684] D'Eustachio, Peter, 2015-02-25
entityFunctionalStatus	[EntityFunctionalStatus:5662849] loss_of_function of DCXR H195Tfs*7 [plasma membrane]
input	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:5660036] L-xylulose [cytosol] [SimpleEntity:29364] NADPH [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660062] Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria [LiteratureReference:5660043] The enzymatic defect in essential pentosuria
modified	[InstanceEdit:5668965] D'Eustachio, Peter, 2015-01-29 [InstanceEdit:5674544] D'Eustachio, Peter, 2015-02-12 [InstanceEdit:5678272] D'Eustachio, Peter, 2015-02-23 [InstanceEdit:5678584] D'Eustachio, Peter, 2015-02-24 [InstanceEdit:6790590] D'Eustachio, Peter, 2015-08-13 [InstanceEdit:6791050] D'Eustachio, Peter, 2015-08-17 [InstanceEdit:9631717] Wu, G, 2018-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective DCXR does not reduce L-xylulose to xylitol
normalReaction	[Reaction:5661240] DCXR tetramer reduces L-xylulose to xylitol [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6791051] Jassal, Bijay, 2015-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797193] R-HSA-5662851.3
summation	[Summation:5662848] Mutations that inactivate DCXR block the conversion of L-xyl...
(hasEvent)	[Pathway:5662853] Essential pentosuria [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778027] Update Tracker - [FailedReaction:5662851] Defective DCXR does not reduce L-xylulose to xylitol - v68:[addCatalystActivity]
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