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Details on Person Tyrosinase oxidises tyrosine to dopaquinone

Class:Id	Reaction:5662662
_displayName	Tyrosinase oxidises tyrosine to dopaquinone
_doRelease	TRUE
_timestamp	2025-03-26 18:58:36
authored	[InstanceEdit:5662656] Jupe, Steve, 2015-01-13
catalystActivity	[CatalystActivity:5662720] catechol oxidase activity of TYR:2xCu2+ [melanosome membrane]
compartment	[Compartment:5668575] melanosome membrane [Compartment:5668572] melanosome lumen
created	[InstanceEdit:5662656] Jupe, Steve, 2015-01-13
crossReference	[DatabaseIdentifier:9942550] RHEA:18118
edited	[InstanceEdit:5673776] Jupe, Steve, 2015-02-10
input	[SimpleEntity:5668567] L-Tyr [melanosome lumen] [SimpleEntity:5668566] O2 [melanosome lumen]
internalReviewed	[InstanceEdit:9943293] D'Eustachio, Peter, 2025-03-26
isChimeric	FALSE
literatureReference	[LiteratureReference:5662697] Mammalin tyrosinase. Stoichiometry and measurement of reaction products [LiteratureReference:8878539] Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes [LiteratureReference:8878538] The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase [LiteratureReference:8878551] Molecular genetics of human pigmentation diversity [LiteratureReference:8878564] Homozygosity mapping and whole-exome sequencing to detect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albinism and neutropenia
modified	[InstanceEdit:5662723] Jupe, Steve, 2015-01-13 [InstanceEdit:5666058] Jupe, Steve, 2015-01-21 [InstanceEdit:5668549] Jupe, Steve, 2015-01-26 [InstanceEdit:5668570] Jupe, Steve, 2015-01-26 [InstanceEdit:5668842] Jupe, Steve, 2015-01-28 [InstanceEdit:5672023] Jupe, Steve, 2015-02-04 [InstanceEdit:5674566] Jupe, Steve, 2015-02-13 [InstanceEdit:5674603] Jupe, Steve, 2015-02-13 [InstanceEdit:8878550] Jassal, Bijay, 2016-07-08 [InstanceEdit:8878570] Jassal, Bijay, 2016-07-08 [InstanceEdit:8934768] Jassal, Bijay, 2016-08-12 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9942545] D'Eustachio, Peter, 2025-03-17 [InstanceEdit:9943292] D'Eustachio, Peter, 2025-03-26 [InstanceEdit:9943295] D'Eustachio, Peter, 2025-03-26
name	Tyrosinase oxidises tyrosine to dopaquinone L-tyrosine + O2 => L-dopaquinone + H2O
output	[SimpleEntity:5662695] L-Dopaquinone [melanosome lumen] [SimpleEntity:5668574] H2O [melanosome lumen]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:8878533] Positive regulation by 'OCA2 [melanosome membrane]' [PositiveRegulation:8878560] Positive regulation by 'SLC45A2 [melanosome membrane]'
regulationReference	[RegulationReference:9641403] Positive regulation by 'SLC45A2 [melanosome membrane]' Homozygosity mapping and whole-exome sequencing to detect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albinism and neutropenia [RegulationReference:9642250] Positive regulation by 'OCA2 [melanosome membrane]' Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes
releaseDate	2015-03-15
reviewed	[InstanceEdit:5674576] Ito, Shosuke, 2015-02-13 [InstanceEdit:5674585] d'Ischia, Marco, 2015-02-13 [InstanceEdit:9943296] Hill, David P, 2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8878570] Jassal, Bijay, 2016-07-08
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679693] R-HSA-5662662.6
structureModified	[InstanceEdit:9942545] D'Eustachio, Peter, 2025-03-17
summation	[Summation:5662672] Melanogenesis is initiated with the first step of tyrosine o...
(hasEvent)	[Pathway:5662702] Melanin biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:5662669] Dopaquinone transforms to Leucodopachrome (Cyclodopa) [Homo sapiens] [Reaction:5672019] Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782896] Update Tracker - [Reaction:5662662] Tyrosinase oxidises tyrosine to dopaquinone - v58:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9953609] Update Tracker - [Reaction:5662662] Tyrosinase oxidises tyrosine to dopaquinone - v93:[add_removeInput, add_removeOutput]
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