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Details on Person Dopachrome is transformed to DHICA by DCT

Class:Id	Reaction:5662660
_displayName	Dopachrome is transformed to DHICA by DCT
_doRelease	TRUE
_timestamp	2025-03-17 20:03:03
authored	[InstanceEdit:5662656] Jupe, Steve, 2015-01-13
catalystActivity	[CatalystActivity:5662688] dopachrome isomerase activity of DCT:2xZn2+ [melanosome membrane]
compartment	[Compartment:5668572] melanosome lumen [Compartment:5668575] melanosome membrane
created	[InstanceEdit:5662656] Jupe, Steve, 2015-01-13
crossReference	[DatabaseIdentifier:9942551] RHEA:13042
edited	[InstanceEdit:5673776] Jupe, Steve, 2015-02-10
input	[SimpleEntity:5662665] Dopachrome [melanosome lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:5662655] Functional analysis of the slaty gene product (TRP2) as dopachrome tautomerase and the effect of a point mutation on its catalytic function
modified	[InstanceEdit:5662723] Jupe, Steve, 2015-01-13 [InstanceEdit:5662886] Jupe, Steve, 2015-01-14 [InstanceEdit:5662944] Jupe, Steve, 2015-01-14 [InstanceEdit:5665927] Jupe, Steve, 2015-01-20 [InstanceEdit:5668549] Jupe, Steve, 2015-01-26 [InstanceEdit:5668570] Jupe, Steve, 2015-01-26 [InstanceEdit:5668842] Jupe, Steve, 2015-01-28 [InstanceEdit:5672023] Jupe, Steve, 2015-02-04 [InstanceEdit:5674566] Jupe, Steve, 2015-02-13 [InstanceEdit:5674603] Jupe, Steve, 2015-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9942545] D'Eustachio, Peter, 2025-03-17
name	Dopachrome is transformed to DHICA by DCT L-dopachrome => 5,6-dihydroxyindole-2-carboxylate
output	[SimpleEntity:5662670] DHICA [melanosome lumen]
precedingEvent	[Reaction:5672019] Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa [Homo sapiens] [Reaction:5662662] Tyrosinase oxidises tyrosine to dopaquinone [Homo sapiens] [Reaction:5662669] Dopaquinone transforms to Leucodopachrome (Cyclodopa) [Homo sapiens]
releaseDate	2015-03-15
reviewed	[InstanceEdit:5674576] Ito, Shosuke, 2015-02-13 [InstanceEdit:5674585] d'Ischia, Marco, 2015-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679876] R-HSA-5662660.3
summation	[Summation:5662721] Dopachrome is converted to DHICA by DCT (Dopachrome tautomer...
(hasEvent)	[Pathway:5662702] Melanin biosynthesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5663050] DHI and DHICA polymerize forming eumelanin [Homo sapiens] [Reaction:8878581] TYRP1 oxidises DHICA to IQCA [Homo sapiens]
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