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Details on Person Expression of GCLC

Class:Id	BlackBoxEvent:5662607
_displayName	Expression of GCLC
_timestamp	2018-10-31 14:01:21
authored	[InstanceEdit:5661316] May, Bruce, 2015-01-09
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:5662602] May, Bruce, 2015-01-12
edited	[InstanceEdit:5661316] May, Bruce, 2015-01-09
inferredFrom	[BlackBoxEvent:5683529] Expression of Gclc [Mus musculus]
input	[EntityWithAccessionedSequence:5662569] GCLC gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5683456] Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses
modified	[InstanceEdit:5683530] May, Bruce, 2015-03-15 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626993] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name	Expression of GCLC
output	[EntityWithAccessionedSequence:174385] GCLC [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5662626] MTF1 dimer:12Zn2+ binds GCLC gene [Homo sapiens] [BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5662633] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:GCLC gene [nucleoplasm]'
regulationReference	[RegulationReference:9641238] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:GCLC gene [nucleoplasm]' Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8879290] R-HSA-5662607.1
summation	[Summation:5683450] The GCLC gene is transcribed to yield mRNA which is translat... [Summation:5684746] As inferred from mouse homologs, MTF1 binds and activates th...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
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No pathways have been reviewed or authored by Expression of GCLC (5662607)