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Details on Person MT3 binds zinc
Class:Id Reaction:5662606
_displayName MT3 binds zinc
_doRelease TRUE
_timestamp 2016-03-12 07:46:41
authored [InstanceEdit:5661316] May, Bruce, 2015-01-09
compartment [Compartment:70101] cytosol
created [InstanceEdit:5662602] May, Bruce, 2015-01-12
edited [InstanceEdit:5661316] May, Bruce, 2015-01-09
input [EntityWithAccessionedSequence:5660396] MT3 [cytosol] [Homo sapiens] [SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:29426] Zn2+ [cytosol] [SimpleEntity:29426] Zn2+ [cytosol]
isChimeric FALSE
literatureReference [LiteratureReference:5662542] Effects of Zn(2+), Ca(2+), and Mg(2+) on the structure of Zn(7)metallothionein-3: evidence for an additional zinc binding site [LiteratureReference:5662513] Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity [LiteratureReference:5662545] Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions [LiteratureReference:5662492] Zn7metallothionein-3 and the synaptic vesicle cycle: interaction of metallothionein-3 with the small GTPase Rab3A [LiteratureReference:5662521] Metal binding of metallothionein-3 versus metallothionein-2: lower affinity and higher plasticity [LiteratureReference:5662501] Purification of recombinant human apometallothionein-3 and reconstitution with zinc [LiteratureReference:5662530] Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively [LiteratureReference:5663004] High level expression, efficient purification, and bioactivity of recombinant human metallothionein 3 (rhMT3) from methylotrophic yeast Pichia pastoris
modified [InstanceEdit:5663006] May, Bruce, 2015-01-14 [InstanceEdit:5683530] May, Bruce, 2015-03-15 [InstanceEdit:6798594] May, Bruce, 2015-09-19 [InstanceEdit:6814143] May, Bruce, 2015-11-25 [InstanceEdit:8864144] May, Bruce, 2016-03-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name MT3 binds zinc
output [Complex:5662573] MT3:7Zn2+ [cytosol] [Homo sapiens]
precedingEvent
releaseDate 2015-12-15
releaseStatus NEW
reviewed [InstanceEdit:6798577] Atrian, Sílvia, 2015-09-19
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:6812379] R-HSA-5662606.4
summation [Summation:5683519] The metallothionein MT3 binds 7 zinc(II) atoms in 2 clusters...
(hasEvent) [Pathway:5661231] Metallothioneins bind metals [Homo sapiens]
(precedingEvent) [BlackBoxEvent:5662613] MT3 exchanges zinc for copper [Homo sapiens]
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