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Details on Person Expression of MT3
Class:Id BlackBoxEvent:5661308
_displayName Expression of MT3
_timestamp 2018-10-31 14:18:23
authored [InstanceEdit:5661239] May, Bruce, 2015-01-09
compartment [Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created [InstanceEdit:5661311] May, Bruce, 2015-01-09
edited [InstanceEdit:5661239] May, Bruce, 2015-01-09
input [EntityWithAccessionedSequence:5661313] MT3 gene [nucleoplasm] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:5674894] Metallothionein gene expression is altered in oral cancer and may predict metastasis and patient outcomes [LiteratureReference:5674707] Expression, regulation and function of human metallothioneins in endothelial cells [LiteratureReference:5674927] Metallothionein 3: an androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells [LiteratureReference:5674641] Expression of metallothionein-III in patients with non-small cell lung cancer [LiteratureReference:5674796] Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues [LiteratureReference:5674645] PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes [LiteratureReference:5674640] Metallothionein isoform 3 and proximal tubule vectorial active transport [LiteratureReference:5674712] Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes [LiteratureReference:5674790] Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd+2 or As+3 transformed human urothelial cells [LiteratureReference:5660248] Gains, losses and changes of function after gene duplication: study of the metallothionein family [LiteratureReference:5690964] Metallothionein isoform 3 expression in human skin, related cancers and human skin derived cell cultures
modified [InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5675919] May, Bruce, 2015-02-18 [InstanceEdit:5690965] May, Bruce, 2015-05-03 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626996] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name Expression of MT3
output [EntityWithAccessionedSequence:5660396] MT3 [cytosol] [Homo sapiens]
precedingEvent
regulatedBy [PositiveGeneExpressionRegulation:5684738] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT3 gene [nucleoplasm]'
regulationReference [RegulationReference:9641590] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT3 gene [nucleoplasm]' Trace element status and zinc homeostasis differ in breast and formula-fed piglets
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:8896136] R-HSA-5661308.1
summation [Summation:5674977] The MT3 gene is transcribed to yield mRNA which is translate... [Summation:5684755] As inferred from pig homologs (Ronis et al. 2015) and comput...
(hasEvent) [Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
(precedingEvent) [Reaction:5662606] MT3 binds zinc [Homo sapiens] [Reaction:5662620] MT3 binds cadmium [Homo sapiens] [Reaction:5663002] MT3 binds copper [Homo sapiens]
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