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Details on Person Expression of MT1F

Class:Id	BlackBoxEvent:5661293
_displayName	Expression of MT1F
_timestamp	2018-10-31 14:16:19
authored	[InstanceEdit:5661239] May, Bruce, 2015-01-09
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:5661311] May, Bruce, 2015-01-09
edited	[InstanceEdit:5661239] May, Bruce, 2015-01-09
input	[EntityWithAccessionedSequence:5660369] MT1F gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660165] Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells [LiteratureReference:5674858] Up-regulation of metallothionein gene expression in parkinsonian astrocytes [LiteratureReference:5674768] Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells [LiteratureReference:5674808] The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma [LiteratureReference:5674894] Metallothionein gene expression is altered in oral cancer and may predict metastasis and patient outcomes [LiteratureReference:5674712] Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes [LiteratureReference:5660347] Functional analyses of promoter elements responsible for the differential expression of the human metallothionein (MT)-IG and MT-IF genes [LiteratureReference:5660248] Gains, losses and changes of function after gene duplication: study of the metallothionein family [LiteratureReference:8954367] Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
modified	[InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5675919] May, Bruce, 2015-02-18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8954377] May, Bruce, 2017-01-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626996] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04
name	Expression of MT1F
output	[EntityWithAccessionedSequence:5660426] MT1F [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5674962] MTF1 dimer:12Zn2+ binds MT1F gene [Homo sapiens] [BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5684741] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT1F gene [nucleoplasm]'
regulationReference	[RegulationReference:9642093] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT1F gene [nucleoplasm]' Functional analyses of promoter elements responsible for the differential expression of the human metallothionein (MT)-IG and MT-IF genes
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8916025] R-HSA-5661293.1
summation	[Summation:5675916] The MT1F gene is transcribed to yield mRNA which is translat...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
(precedingEvent)	[Reaction:5662596] MT1F binds cadmium [Homo sapiens] [Reaction:5662623] MT1F binds zinc [Homo sapiens]
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No pathways have been reviewed or authored by Expression of MT1F (5661293)