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Details on Person Expression of MT1E

Class:Id	BlackBoxEvent:5661292
_displayName	Expression of MT1E
_timestamp	2018-10-31 14:16:02
authored	[InstanceEdit:5661239] May, Bruce, 2015-01-09
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:5661311] May, Bruce, 2015-01-09
edited	[InstanceEdit:5661239] May, Bruce, 2015-01-09
input	[EntityWithAccessionedSequence:5660375] MT1E gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5674707] Expression, regulation and function of human metallothioneins in endothelial cells [LiteratureReference:5674852] DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium [LiteratureReference:5660206] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines [LiteratureReference:5674764] Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration [LiteratureReference:5674888] Water-soluble genistin glycoside isoflavones up-regulate antioxidant metallothionein expression and scavenge free radicals [LiteratureReference:5674829] Low-level arsenite induced gene expression in HEK293 cells [LiteratureReference:5674858] Up-regulation of metallothionein gene expression in parkinsonian astrocytes [LiteratureReference:5674712] Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes [LiteratureReference:5660828] Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals [LiteratureReference:5660248] Gains, losses and changes of function after gene duplication: study of the metallothionein family [LiteratureReference:8954367] Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
modified	[InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5675919] May, Bruce, 2015-02-18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8954377] May, Bruce, 2017-01-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626996] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name	Expression of MT1E
output	[EntityWithAccessionedSequence:5660420] MT1E [cytosol] [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5684733] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT1E gene [nucleoplasm]'
regulationReference	[RegulationReference:9641508] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT1E gene [nucleoplasm]' Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8921858] R-HSA-5661292.1
summation	[Summation:5674981] The MT1E gene is transcribed to yield mRNA which is translat... [Summation:5684751] As inferred from the induction of MT1E by zinc (Vandeghinste...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
(precedingEvent)	[Reaction:5662595] MT1E binds cadmium [Homo sapiens] [Reaction:5662614] MT1E binds zinc [Homo sapiens]
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No pathways have been reviewed or authored by Expression of MT1E (5661292)