Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane

Class:Id	FailedReaction:5660910
_displayName	Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane
_doRelease	TRUE
_timestamp	2015-09-04 20:51:12
authored	[InstanceEdit:5660943] Jassal, Bijay, 2015-01-07
catalystActivity	[CatalystActivity:9631923] amino acid transmembrane transporter activity of SLC3A2:SLC7A7 mutants [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5660943] Jassal, Bijay, 2015-01-07
disease	[Disease:5625037] amino acid metabolic disorder
edited	[InstanceEdit:5660943] Jassal, Bijay, 2015-01-07
entityFunctionalStatus	[EntityFunctionalStatus:5660833] loss_of_function of SLC3A2:SLC7A7 mutants [plasma membrane]
input	[SimpleEntity:29468] L-Arg [cytosol] [SimpleEntity:351964] L-Leu [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660851] SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance [LiteratureReference:5660884] Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene [LiteratureReference:5660887] Structure of the SLC7A7 gene and mutational analysis of patients affected by lysinuric protein intolerance [LiteratureReference:5660886] Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene
modified	[InstanceEdit:5663019] Jassal, Bijay, 2015-01-14 [InstanceEdit:6789777] Jassal, Bijay, 2015-08-04 [InstanceEdit:9631717] Wu, G, 2018-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane
normalReaction	[Reaction:379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797185] R-HSA-5660910.3
summation	[Summation:5660938] SLC7A7 encodes the y+L amino acid transporter 1 (y+LAT1). As...
(hasEvent)	[Pathway:5619093] Defective SLC7A7 in vascular wall interactions causes lysinuric protein intolerance (LPI) [Homo sapiens] [Pathway:5660862] Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778037] Update Tracker - [FailedReaction:5660910] Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane - v68:[addCatalystActivity]
[Change default viewing format]

No pathways have been reviewed or authored by Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (5660910)