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Details on Person Antifungal immunity through the induction of T-helper 17 cel...
| Class:Id | Summation:5660587 |
|---|---|
| _displayName | Antifungal immunity through the induction of T-helper 17 cel... |
| _timestamp | 2015-01-14 17:03:00 |
| created | [InstanceEdit:5660613] Garapati, P V, 2015-01-04 |
| literatureReference | [LiteratureReference:5660589] The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans [LiteratureReference:5660611] Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome |
| modified | [InstanceEdit:5663011] Garapati, P V, 2015-01-14 |
| text | Antifungal immunity through the induction of T-helper 17 cells (TH17) responses requires the production of mature, active interleukin-1beta (IL1B). CLEC7A (dectin-1) through the SYK route induces activation of NF-kB and transcription of the gene encoding pro-IL1B via the CARD9-BCL10-MALT1 complex as well as the formation and activation of a MALT1-caspase-8-ASC complex that mediated the processing of pro-IL1B. The inactive precursor pro-IL1B has to be processed into mature bioactive form of IL1B and is usually mediated by inflammatory cysteine protease caspase-1. Gringhuis et al. showed that CLEC7A mediated processing of IL1B occurs through two distinct mechanisms: CLEC7A triggering induced a primary noncanonical caspase-8 inflammasome for pro-IL1B processing that was independent of caspase-1 activity, whereas some fungi triggered a second additional mechanism that required activation of the NLRP3/caspase 1 inflammasome. Unlike the canonical caspase-1 inflammasome, CLEC7A mediated noncanonical caspase-8-dependent inflammasome is independent of pathogen internalization. CLEC7A/inflammasome pathway enables the host immune system to mount a protective TH17 response against fungi and bacterial infection (Gringhuis et al. 2012, Cheng et al. 2011). |
| (summation) | [Pathway:5660668] CLEC7A/inflammasome pathway [Homo sapiens] |
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