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Details on Person MTF1 dimer:12Zn2+ binds MT1G gene

Class:Id	Reaction:5660529
_displayName	MTF1 dimer:12Zn2+ binds MT1G gene
_timestamp	2016-07-15 23:49:31
authored	[InstanceEdit:5660523] May, Bruce, 2014-12-27
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
edited	[InstanceEdit:5660523] May, Bruce, 2014-12-27
inferredFrom	[Reaction:5660505] Mtf1 dimer:12Zn2+, Sp1, Ep300, and Nfi dimer bind Mt1 gene [Mus musculus]
input	[Complex:5660456] MTF1 dimer:12Zn2+ [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5660385] MT1G gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660347] Functional analyses of promoter elements responsible for the differential expression of the human metallothionein (MT)-IG and MT-IF genes [LiteratureReference:5660211] Functional analyses of the human metallothionein-IG gene. In vitro and in vivo studies [LiteratureReference:5660309] Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G, and MTII-A genes in the hepatoblastoma cell line (HepG2) [LiteratureReference:5660224] Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure [LiteratureReference:5660257] Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors [LiteratureReference:6798600] Differential quantitative zinc-induced expression of human metallothionein isogenes in haematopoietic precursor cell lines
modified	[InstanceEdit:5675919] May, Bruce, 2015-02-18 [InstanceEdit:6798601] May, Bruce, 2015-09-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	MTF1 dimer:12Zn2+ binds MT1G gene
output	[Complex:5660443] MTF1 dimer:12Zn2+:MT1G gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens] [Reaction:5660494] MTF1 dimer binds zinc [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8897211] R-HSA-5660529.1
summation	[Summation:5675910] The MT1G gene is inducible by zinc, copper, and cadmium (Sad...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
(inferredFrom)	[Reaction:5674960] MTF1 dimer:12Zn2+ binds MT1A gene [Homo sapiens] [Reaction:5674961] MTF1 dimer:12Zn2+ binds MT1E gene [Homo sapiens] [Reaction:5674965] MTF1 dimer:12Zn2+ binds MT1H gene [Homo sapiens] [Reaction:5674969] MTF1 dimer:12Zn2+ binds MT1X gene [Homo sapiens] [Reaction:5674970] MTF1 dimer:12Zn2+ binds MT1M gene [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5660477] Expression of MT1G [Homo sapiens]
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No pathways have been reviewed or authored by MTF1 dimer:12Zn2+ binds MT1G gene (5660529)