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Details on Person Expression of SLC40A1 (FPN1)

Class:Id	BlackBoxEvent:5660527
_displayName	Expression of SLC40A1 (FPN1)
_timestamp	2018-10-31 14:36:00
authored	[InstanceEdit:5660523] May, Bruce, 2014-12-27
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
edited	[InstanceEdit:5660523] May, Bruce, 2014-12-27
inferredFrom	[BlackBoxEvent:5660507] Expression of Slc40a1 (Fpn1, Mtp1) [Mus musculus]
input	[EntityWithAccessionedSequence:5660421] SLC40A1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5674884] Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1 [LiteratureReference:5674776] The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression [LiteratureReference:5674643] Expression of alternative transcripts of ferroportin-1 during human erythroid differentiation
modified	[InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5676005] May, Bruce, 2015-02-18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627001] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name	Expression of SLC40A1 (FPN1)
output	[EntityWithAccessionedSequence:442390] SLC40A1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5660509] MTF1 dimer:12Zn2+ binds SLC40A1 gene [Homo sapiens] [BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5660548] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:SLC40A1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641780] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:SLC40A1 gene [nucleoplasm]' Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8901957] R-HSA-5660527.1
summation	[Summation:5676001] The SLC40A1 (Ferroportin, FPN1) gene is transcribed to yield... [Summation:5684760] As inferred from mouse homologs, MTF1;zinc binds metal resp...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
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No pathways have been reviewed or authored by Expression of SLC40A1 (FPN1) (5660527)