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Details on Person Expression of MT1A

Class:Id	BlackBoxEvent:5660516
_displayName	Expression of MT1A
_timestamp	2018-10-31 14:15:28
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
input	[EntityWithAccessionedSequence:5660409] MT1A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660214] Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1 [LiteratureReference:5660331] Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure [LiteratureReference:5660165] Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells [LiteratureReference:5660206] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines [LiteratureReference:5660267] The human metallothionein gene family: structure and expression [LiteratureReference:5660248] Gains, losses and changes of function after gene duplication: study of the metallothionein family [LiteratureReference:5660316] Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes [LiteratureReference:5660795] Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes [LiteratureReference:5660811] Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues [LiteratureReference:5660828] Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals [LiteratureReference:5660813] Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA [LiteratureReference:5674888] Water-soluble genistin glycoside isoflavones up-regulate antioxidant metallothionein expression and scavenge free radicals [LiteratureReference:5674712] Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes [LiteratureReference:8954367] Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
modified	[InstanceEdit:5660829] May, Bruce, 2015-01-07 [InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5675919] May, Bruce, 2015-02-18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8954377] May, Bruce, 2017-01-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626996] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name	Expression of MT1A
output	[EntityWithAccessionedSequence:5660412] MT1A [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5674960] MTF1 dimer:12Zn2+ binds MT1A gene [Homo sapiens] [BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5660798] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT1A gene [nucleoplasm]'
regulationReference	[RegulationReference:9641645] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:MT1A gene [nucleoplasm]' Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8891191] R-HSA-5660516.1
summation	[Summation:5675908] The MT1A gene is transcribed to yield mRNA which is translat... [Summation:5684765] As inferred from the mouse homolog (Radtke et al. 1993) and ...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
(precedingEvent)	[Reaction:5661217] MT1A binds zinc [Homo sapiens] [Reaction:5661219] MT1A binds cadmium [Homo sapiens] [Reaction:5661230] MT1A binds arsenic [Homo sapiens]
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No pathways have been reviewed or authored by Expression of MT1A (5660516)