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Details on Person Expression of LCN1

Class:Id	BlackBoxEvent:5660486
_displayName	Expression of LCN1
_timestamp	2018-10-31 14:11:53
authored	[InstanceEdit:5660523] May, Bruce, 2014-12-27
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
edited	[InstanceEdit:5660523] May, Bruce, 2014-12-27
input	[EntityWithAccessionedSequence:5660394] LCN1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5674763] Tear lipocalin is the predominant phosphoprotein in human tear fluid [LiteratureReference:5674756] Human lipocalin-1, a physiological scavenger of lipophilic compounds, is produced by corticotrophs of the pituitary gland [LiteratureReference:5674654] Tissue expression of tear lipocalin in humans [LiteratureReference:5674678] Expression of the gene for tear lipocalin/von Ebner's gland protein in human prostate [LiteratureReference:5674778] Tissue expression of lipocalins in human lacrimal and von Ebner's glands: colocalization with lysozyme [LiteratureReference:5674673] Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands [LiteratureReference:5660285] Target gene search for the metal-responsive transcription factor MTF-1
modified	[InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5683530] May, Bruce, 2015-03-15 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626995] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04
name	Expression of LCN1
output	[EntityWithAccessionedSequence:5229284] LCN1 [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:5660513] MTF1 dimer:12Zn2+ binds LCN1 gene [Homo sapiens] [BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5684734] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:LCN1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642462] Positive gene expression regulation by 'MTF1 dimer:12Zn2+:LCN1 gene [nucleoplasm]' Target gene search for the metal-responsive transcription factor MTF-1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8896531] R-HSA-5660486.1
summation	[Summation:5674974] The LCN1 (tear lipocalin, von Ebner's gland protein) gene is...
(hasEvent)	[Pathway:5660489] MTF1 activates gene expression [Homo sapiens]
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No pathways have been reviewed or authored by Expression of LCN1 (5660486)