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Details on Person Mtf1 dimer:12Zn2+ translocates from cytosol to nucleus

Class:Id	BlackBoxEvent:5660482
_displayName	Mtf1 dimer:12Zn2+ translocates from cytosol to nucleus
_timestamp	2017-10-19 13:56:06
authored	[InstanceEdit:5660523] May, Bruce, 2014-12-27
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
edited	[InstanceEdit:5660523] May, Bruce, 2014-12-27
input	[Complex:5660463] Mtf1 dimer:12Zn2+ [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:5660105] Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux [LiteratureReference:5674893] Zinc and cadmium can promote rapid nuclear translocation of metal response element-binding transcription factor-1 [LiteratureReference:5660182] Putative zinc-sensing zinc fingers of metal-response element-binding transcription factor-1 stabilize a metal-dependent chromatin complex on the endogenous metallothionein-I promoter [LiteratureReference:5660159] The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers [LiteratureReference:9026352] Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
modified	[InstanceEdit:5674976] May, Bruce, 2015-02-14 [InstanceEdit:5675919] May, Bruce, 2015-02-18 [InstanceEdit:5683567] May, Bruce, 2015-03-16 [InstanceEdit:5690961] May, Bruce, 2015-05-02 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9026355] May, Bruce, 2017-10-19
name	Mtf1 dimer:12Zn2+ translocates from cytosol to nucleus
output	[Complex:5660455] Mtf1 dimer:12Zn2+ [nucleoplasm] [Mus musculus]
precedingEvent	[Reaction:5660517] Mtf1 dimer binds zinc [Mus musculus]
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:8884841] R-MMU-5660482.1
summation	[Summation:5674980] Mtf1 accumulates in the nucleus in response to binding zinc ...
(inferredFrom)	[BlackBoxEvent:5660525] MTF1 dimer:12Zn2+ translocates from cytosol to nucleus [Homo sapiens]
(precedingEvent)	[Reaction:5660470] Mtf1 dimer:12Zn2+ binds Csrp1 gene [Mus musculus] [Reaction:5660481] Mtf1 dimer:12Zn2+ binds Sepw1 gene [Mus musculus] [Reaction:5660488] Mtf1 dimer:12Zn2+ binds Usp24 gene [Mus musculus] [Reaction:5660490] Mtf1 dimer:12Zn2+ binds Afp gene [Mus musculus] [Reaction:5660492] Mtf1 dimer:12Zn2+ binds Ndrg1 gene [Mus musculus] [Reaction:5660500] Mtf1 dimer:12Zn2+ binds Armcx2 gene [Mus musculus] [Reaction:5660505] Mtf1 dimer:12Zn2+, Sp1, Ep300, and Nfi dimer bind Mt1 gene [Mus musculus] [Reaction:5660508] Mtf1 dimer:12Zn2+ binds Fcgr1 gene [Mus musculus] [Reaction:5660512] Mtf1 dimer:12Zn2+ binds Slc40a1 gene [Mus musculus] [Reaction:5662594] Mtf1 dimer:12Zn2+ binds Slc39a10 (Zip10) gene [Mus musculus] List all 13 refering instances
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