Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q03014 HHEX
| Class:Id | ReferenceGeneProduct:56600 |
|---|---|
| _chainChangeLog | chain:1-270 added on Fri February 6 2015 |
| _displayName | UniProt:Q03014 HHEX |
| _timestamp | 2024-11-03 20:10:12 |
| chain | chain:1-270 |
| checksum | 9C16BB6D494475FC |
| comment | FUNCTION Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636).SUBUNIT Interacts with CD81; the interaction prevents nuclear translocation of HHEX (By similarity). Interacts (via N-terminus) with SOX13; abolishes the SOX13-mediated inhibition of WNT-mediated transcriptional activity via competitive inhibition of the SOX13-TCF7 complex (PubMed:20028982). Interacts with EIF4E; the interaction inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669).INTERACTION Liver and promyelocytic leukemia cell line HL-60.DEVELOPMENTAL STAGE Expressed during hematopoiesis. |
| description | recommendedName: Hematopoietically-expressed homeobox protein HHEX shortName: Homeobox protein HEX alternativeName: Homeobox protein PRH alternativeName: fullName evidence="9"Proline-rich homeodomain protein |
| geneName | HHEX HEX PRH PRHX |
| identifier | Q03014 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Developmental protein Differentiation DNA-binding Homeobox Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HHEX |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888900] ENSEMBL:ENSG00000152804 HHEX [Homo sapiens] |
| secondaryIdentifier | HHEX_HUMAN B1AQ17 Q96CE9 |
| sequenceLength | 270 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:452702] HHEX [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q03014 HHEX (56600)
