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Details on Person Defective SI does not hydrolyze Suc
| Class:Id | FailedReaction:5659926 |
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| _displayName | Defective SI does not hydrolyze Suc |
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| _doRelease | TRUE |
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| _timestamp | 2015-03-04 04:19:05 |
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| authored | [InstanceEdit:5675275] D'Eustachio, Peter, 2015-02-15 |
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| catalystActivity | [CatalystActivity:9631835] sucrose alpha-glucosidase activity of SI mutant dimers [plasma membrane] |
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| compartment | [Compartment:984] extracellular region
[Compartment:876] plasma membrane |
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| created | [InstanceEdit:5659925] D'Eustachio, Peter, 2014-12-23 |
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| disease | [Disease:5659880] intestinal disaccharidase deficiency |
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| edited | [InstanceEdit:5675275] D'Eustachio, Peter, 2015-02-15 |
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| entityFunctionalStatus | [EntityFunctionalStatus:5659891] loss_of_function of SI mutant dimers [plasma membrane] |
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| inferredFrom |
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| input | [SimpleEntity:188980] Suc [extracellular region]
[SimpleEntity:109276] H2O [extracellular region] |
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| literatureReference | [LiteratureReference:5659889] Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption
[LiteratureReference:5659866] Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains |
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| modified | [InstanceEdit:5659928] D'Eustachio, Peter, 2014-12-23
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
[InstanceEdit:5668963] D'Eustachio, Peter, 2015-01-29
[InstanceEdit:5674548] D'Eustachio, Peter, 2015-02-12
[InstanceEdit:5675267] D'Eustachio, Peter, 2015-02-15
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective SI does not hydrolyze Suc |
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| normalReaction |
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| releaseDate | 2015-03-19 |
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| reviewed | [InstanceEdit:5675273] Naim, Hassan Y, Amiri, Mahdi, 2015-02-15
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:5680309] R-HSA-5659926.3 |
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| summation | [Summation:5659927] Mutations that disrupt the catalytic activity or strongly in... |
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| (hasEvent) | [Pathway:5659898] Intestinal saccharidase deficiencies [Homo sapiens] |
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| (updatedInstance) | [_UpdateTracker:9778159] Update Tracker - [FailedReaction:5659926] Defective SI does not hydrolyze Suc - v68:[addCatalystActivity] |
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