Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person Mutations that disrupt the catalytic activity or strongly in...
| Class:Id | Summation:5659908 |
|---|---|
| _displayName | Mutations that disrupt the catalytic activity or strongly in... |
| _timestamp | 2015-02-15 17:43:45 |
| created | [InstanceEdit:5659876] D'Eustachio, Peter, 2014-12-23 |
| modified | [InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:5675267] D'Eustachio, Peter, 2015-02-15 |
| text | Mutations that disrupt the catalytic activity or strongly interfere with proper folding, glycosylation and transport of SI (sucrase-isomaltase) are inferred to block the cleavage of isomaltose (iMal) to glucose, based on the experimentally demonstrated failure of these SI mutant proteins to hydrolyze maltose (e.g., Sander et al. 2006) and the broad substrate specificity of the normal enzyme (Sim et al. 2010). |
| (summation) | [FailedReaction:5659879] Defective SI does not hydrolyze iMal [Homo sapiens] |
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No pathways have been reviewed or authored by Mutations that disrupt the catalytic activity or strongly in... (5659908)
