Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person BRCA1 and BARD1 form a stable heterodimer through an interac...
| Class:Id | Summation:5659789 |
|---|---|
| _displayName | BRCA1 and BARD1 form a stable heterodimer through an interac... |
| _timestamp | 2021-08-16 21:47:17 |
| created | [InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23 |
| modified | [InstanceEdit:5659842] Orlic-Milacic, Marija, 2014-12-23 [InstanceEdit:5687903] Orlic-Milacic, Marija, 2015-04-10 [InstanceEdit:6784211] Orlic-Milacic, Marija, 2015-06-18 [InstanceEdit:6784925] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:9706946] Orlic-Milacic, Marija, 2020-11-09 [InstanceEdit:9706948] Orlic-Milacic, Marija, 2020-11-09 [InstanceEdit:9707090] Orlic-Milacic, Marija, 2020-11-10 [InstanceEdit:9750852] Orlic-Milacic, Marija, 2021-08-16 |
| text | BRCA1 and BARD1 form a stable heterodimer through an interaction between sequences encompassing their N-terminal RING domains (Wu et al. 1996, Brzovic et al. 2001). In addition to the RING domains, BRCA1 and BARD1 both have tandem BRCT motifs at their C termini. The central region of BARD1 contains ankyrin repeats (Wu et al. 1996). Formation of BRCA1:BARD1 heterodimers is necessary for the repair of double-strand DNA breaks by homologous recombination (Westermark et al. 2003, Laufer et al. 2007), BRCA1-mediated tumor suppression (Shakya et al. 2008) and normal development (McCarthy et al. 2003). Tumorigenic BRCA1 mutations that abolish the formation of BRCA1:BARD1 heterodimers have been reported (Wu et al. 1996, Brzovic et al. 2001). |
| (summation) | [Reaction:5659781] BRCA1 forms a heterodimer with BARD1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by BRCA1 and BARD1 form a stable heterodimer through an interac... (5659789)
