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Details on Person BRCA1 forms a heterodimer with BARD1

Class:Id	Reaction:5659781
_displayName	BRCA1 forms a heterodimer with BARD1
_doRelease	TRUE
_timestamp	2020-11-12 14:58:44
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[EntityWithAccessionedSequence:50949] BRCA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5659775] BARD1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5659810] Identification of a RING protein that can interact in vivo with the BRCA1 gene product [LiteratureReference:5659825] Structure of a BRCA1-BARD1 heterodimeric RING-RING complex [LiteratureReference:5659799] BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks [LiteratureReference:5659777] Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair [LiteratureReference:5659798] Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability [LiteratureReference:5659807] The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression
modified	[InstanceEdit:5659842] Orlic-Milacic, Marija, 2014-12-23 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693226] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784750] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9706947] Orlic-Milacic, Marija, 2020-11-09 [InstanceEdit:9707068] Orlic-Milacic, Marija, 2020-11-10 [InstanceEdit:9707090] Orlic-Milacic, Marija, 2020-11-10 [InstanceEdit:9707283] Orlic-Milacic, Marija, 2020-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRCA1 forms a heterodimer with BARD1
output	[Complex:5659802] BRCA1:BARD1 [nucleoplasm] [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12 [InstanceEdit:9706944] Baer, Richard J, 2020-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796658] R-HSA-5659781.4
summation	[Summation:5659789] BRCA1 and BARD1 form a stable heterodimer through an interac...
(hasEvent)	[Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens]
(normalReaction)	[FailedReaction:9663194] Some pathogenic BRCA1 mutants do not bind BARD1 [Homo sapiens] [FailedReaction:9699163] Defective BARD1 does not bind BRCA1 [Homo sapiens]
(precedingEvent)	[Reaction:5683385] Formation of BRCA1-A complex at DNA DSBs [Homo sapiens] [Reaction:9701000] BRCA1:BARD1 heterodimer autoubiquitinates [Homo sapiens] [Reaction:9701003] BAP1 binds BRCA1:BARD1 heterodimer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775885] Update Tracker - [Reaction:5659781] BRCA1 forms a heterodimer with BARD1 - v78:[modifyText] [_UpdateTracker:9776635] Update Tracker - [Reaction:5659781] BRCA1 forms a heterodimer with BARD1 - v75:[modifyText, removeLiteratureReference, removeRegulator] [_UpdateTracker:9783068] Update Tracker - [Reaction:5659781] BRCA1 forms a heterodimer with BARD1 - v57:[addRegulator]
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