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Details on Person RAS GAPs bind RAS:GTP

Class:Id	Reaction:5658435
_displayName	RAS GAPs bind RAS:GTP
_doRelease	TRUE
_timestamp	2016-02-29 20:28:02
authored	[InstanceEdit:5656075] Rothfels, Karen, 2014-12-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5658432] Rothfels, Karen, 2014-12-18
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
input	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [DefinedSet:5658216] RAS GAPs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5658234] Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis [LiteratureReference:5658433] Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP [LiteratureReference:5658404] Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras [LiteratureReference:208211] The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
modified	[InstanceEdit:5675248] Rothfels, Karen, 2015-02-15 [InstanceEdit:5678385] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690584] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691260] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692909] Rothfels, Karen, 2015-05-13 [InstanceEdit:8856653] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS GAPs bind RAS:GTP
output	[Complex:5658227] p21 RAS:GTP:RAS GAPs [plasma membrane] [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	UPDATED
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28 [InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695693] R-HSA-5658435.3
summation	[Summation:5658434] The human genome encodes at least 10 proteins that bind RAS ...
(hasEvent)	[Pathway:5658442] Regulation of RAS by GAPs [Homo sapiens]
(normalReaction)	[FailedReaction:9651280] RAS GAP mutants aren't stimulated by GAPs [Homo sapiens]
(precedingEvent)	[Reaction:5658231] RAS GAPs stimulate RAS GTPase activity [Homo sapiens]
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No pathways have been reviewed or authored by RAS GAPs bind RAS:GTP (5658435)