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Details on Person NF1 levels are controlled by proteasomal degradation in resp...
| Class:Id | Summation:5658425 |
|---|---|
| _displayName | NF1 levels are controlled by proteasomal degradation in resp... |
| _timestamp | 2015-02-05 21:03:12 |
| created | [InstanceEdit:5658419] Rothfels, Karen, 2014-12-18 |
| modified | [InstanceEdit:5672583] Rothfels, Karen, 2015-02-05 |
| text | NF1 levels are controlled by proteasomal degradation in response to stimulation by some growth factors (Cichowski et al, 2003). Ubiquitination is mediated by the CUL3:RBX1 RING E3 ligase complex in conjunction with the BTB adaptor protein KBTBD7 (Hollstein et al, 2013). After its initial rapid degradation, NF1 protein levels are re-established shortly after growth factor treatment, allowing appropriate termination of RAS MAPK signaling (Cichowski et al, 2003). Aberrant destabilization of NF1 by CUL3:KBTBD7-mediated proteasomal degradation has been identified in cases of glioblastoma and depends on activation of PKC alpha (Cichowski et al, 2003; McGillicuddy et al, 2009; Hollstein et al, 2013). |
| (summation) | [Reaction:5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1 [Homo sapiens] |
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