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Details on Person Defective LCT does not hydrolyze Lac

Class:IdFailedReaction:5658001
_displayNameDefective LCT does not hydrolyze Lac
_doReleaseTRUE
_timestamp2015-03-04 04:00:57
authored[InstanceEdit:5675275] D'Eustachio, Peter, 2015-02-15
catalystActivity[CatalystActivity:9631958] lactase activity of LCT mutant dimers [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:5657976] D'Eustachio, Peter, 2014-12-16
disease[Disease:5657999] lactose intolerance
edited[InstanceEdit:5675275] D'Eustachio, Peter, 2015-02-15
entityFunctionalStatus[EntityFunctionalStatus:5658005] loss_of_function of LCT mutant dimers [plasma membrane]
input[SimpleEntity:188973] Lac [extracellular region]
[SimpleEntity:109276] H2O [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:5657979] Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency
[LiteratureReference:5657992] Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD)
modified[InstanceEdit:5658023] D'Eustachio, Peter, 2014-12-16
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
[InstanceEdit:5668963] D'Eustachio, Peter, 2015-01-29
[InstanceEdit:5674548] D'Eustachio, Peter, 2015-02-12
[InstanceEdit:5675267] D'Eustachio, Peter, 2015-02-15
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective LCT does not hydrolyze Lac
normalReaction
releaseDate2015-03-19
reviewed[InstanceEdit:5675273] Naim, Hassan Y, Amiri, Mahdi, 2015-02-15
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680005] R-HSA-5658001.3
summation[Summation:5657978] Mutations that disrupt the catalytic activity of LCT (lactas...
(hasEvent)[Pathway:5659898] Intestinal saccharidase deficiencies [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778562] Update Tracker - [FailedReaction:5658001] Defective LCT does not hydrolyze Lac - v68:[addCatalystActivity]
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