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Details on Person During TNF-alpha or Fas ligand-induced apoptosis TRAF1 can b...

Class:IdSummation:5657939
_displayNameDuring TNF-alpha or Fas ligand-induced apoptosis TRAF1 can b...
_timestamp2015-05-12 19:46:04
created[InstanceEdit:5657940] Shamovsky, V, 2014-12-16
literatureReference[LiteratureReference:5657914] Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death
[LiteratureReference:5634170] Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation
[LiteratureReference:5634227] TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis
[LiteratureReference:5657941] Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis
modified[InstanceEdit:5660773] Shamovsky, V, 2015-01-06
[InstanceEdit:5692530] Shamovsky, Veronica, 2015-05-12
textDuring TNF-alpha or Fas ligand-induced apoptosis TRAF1 can be processed into two fragments (Imler M et al. 2000; Leo E et al. 2001). Caspases-3, -6 and most efficiently caspase-8 cleave TRAF1 in vitro (Imler M et al. 2000; Leo E et al. 2001). Cleavage of TRAF1 occurs at the Asp-163 residue. A mutant TRAF1 (Asp163Ala) was not processed by either caspase (Imler M et al. 2000). The C-terminal cleavage product of TRAF1 was found to inhibit the induction of NFkB when co-expressed with NFkB inducers (such as TNFR1, DR3, TNFR2, Fas etc.) in human embryonic kidney 293 (HEK293) cells or upon treatment with TNF (Imler M et al. 2000; Henkler F et al. 2003). Furthermore, co-transfection of VSV-tagged IKKbeta and TRAF1(truncated or wild-type) into HEK293 or Jurkat T-cells followed by anti-VSV immunoprecipitation coupled with GST-IkB alpha immunocomplex kinase assays for IKK activity revealed that the caspase-generated TRAF1-fragment, but not TRAF1 itself inhibited IKK activation (Henkler F et al. 2003).
(summation)[BlackBoxEvent:5634228] TRAF1 is cleaved by caspases [Homo sapiens]
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