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Details on Person MAPK activating death domain (MADD) and DENN-SV are known to...

Class:IdSummation:5657769
_displayNameMAPK activating death domain (MADD) and DENN-SV are known to...
_timestamp2015-05-12 04:41:33
created[InstanceEdit:5657736] Shamovsky, V, 2014-12-16
literatureReference[LiteratureReference:5657794] IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs
[LiteratureReference:5657799] Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3
[LiteratureReference:5657803] MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival
[LiteratureReference:5657759] Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle
[LiteratureReference:5657782] Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene
[LiteratureReference:5657750] MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells
[LiteratureReference:5657788] Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis
[LiteratureReference:5657806] MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment
modified[InstanceEdit:5660777] Shamovsky, V, 2015-01-06
[InstanceEdit:5692397] Shamovsky, Veronica, 2015-05-12
textMAPK activating death domain (MADD) and DENN-SV are known to directly interact with TNFR1 cytoplasmic tail (Al-Zoubi AM et al. 2001). MADD and DENN-SV are two of at least six splice variants of IG20 gene. MADD and DENN-SV are constitutively expressed in all tissues and at much higher levels in cancer cells and tissues (Al-Zoubi AM et al. 2001; Lim KM et al. 2004). The expression of other IG20 isoforms, such as KIAA0358 and IG20-SV4, can be restricted to certain neuronal tissues (Li L et al. 2008). Regulation of expression of various splice variants can profoundly affect cancer cell survival, proliferation, or death (Efimova EV et al. 2004). Knockdown of IG20 using short hairpin RNA (shRNA) resulted in spontaneous apoptosis in HeLa (cervical cancer), PA-1 (ovarian carcinoma), WRO (follicular carcinoma) and FRO (anaplastic carcinoma) cells (Mulherkar N et al. 2006; Mulherkar N. et al. 2007; Subramanian M et al. 2009). MADD and DENN-SV have been shown to stimulate TNF-alpha and TRAIL-induced upregulation of prosurvival proteins suppressing caspase-8 activation (Kurada BR et al. 2009; Mulherkar N. et al. 2007; Subramanian M et al. 2009).
(summation)[Reaction:5626953] TNF-α:TNFR1 binds DENN/MADD [Homo sapiens]
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