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Details on Person MGMT binds alkylated DNA containing 6-O-methylguanine

Class:Id	Reaction:5657651
_displayName	MGMT binds alkylated DNA containing 6-O-methylguanine
_doRelease	TRUE
_timestamp	2021-05-28 15:15:27
authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
goBiologicalProcess	[GO_BiologicalProcess:17672] DNA alkylation repair
input	[GenomeEncodedEntity:5657606] 6-OMeG-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5657631] MGMT:Zn2+ [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:69939] Regulation of repair of alkylation damage in mammalian genomes. [LiteratureReference:5657611] Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding [LiteratureReference:5657661] The structure of the human AGT protein bound to DNA and its implications for damage detection [LiteratureReference:5657623] A new model for how O6-methylguanine-DNA methyltransferase binds DNA
modified	[InstanceEdit:5657666] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5674552] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5678318] Orlic-Milacic, Marija, 2015-02-23 [InstanceEdit:9732695] Orlic-Milacic, Marija, 2021-05-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MGMT binds alkylated DNA containing 6-O-methylguanine
output	[Complex:5657662] MGMT:Zn2+:6-OMeG-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9732692] Triazenes produce DNA damage in the form of O6-methylguanine [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5657608] Orlic-Milacic, Marija, 2014-12-15
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680353] R-HSA-5657651.3
summation	[Summation:5657664] MGMT recognizes and binds DNA containing 6-O-methylguanine i...
(hasEvent)	[Pathway:5657655] MGMT-mediated DNA damage reversal [Homo sapiens]
(precedingEvent)	[Reaction:73892] MGMT/hAGT mediated DNA Damage Reversal [Homo sapiens]
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No pathways have been reviewed or authored by MGMT binds alkylated DNA containing 6-O-methylguanine (5657651)