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Details on Person ALKBH2 binds alkylated DNA containing 1-etA

Class:Id	Reaction:5657649
_displayName	ALKBH2 binds alkylated DNA containing 1-etA
_doRelease	TRUE
_timestamp	2022-09-13 18:03:38
authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
input	[GenomeEncodedEntity:5657646] 1-etA-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5656464] ALKBH2:Fe2+ [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:113684] Reversal of DNA alkylation damage by two human dioxygenases. [LiteratureReference:5657645] Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA [LiteratureReference:5657644] Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3
modified	[InstanceEdit:5657666] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5674552] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5678318] Orlic-Milacic, Marija, 2015-02-23 [InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALKBH2 binds alkylated DNA containing 1-etA
output	[Complex:5657636] ALKBH2:Fe2+:1-etA-dsDNA [nucleoplasm] [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680168] R-HSA-5657649.3
summation	[Summation:5657635] ALKBH2 binds alkylated DNA containing 1-ethyladenine (1-etA)...
(hasEvent)	[Pathway:112122] ALKBH2 mediated reversal of alkylation damage [Homo sapiens]
(precedingEvent)	[Reaction:112121] Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 [Homo sapiens]
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No pathways have been reviewed or authored by ALKBH2 binds alkylated DNA containing 1-etA (5657649)