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Details on Person ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA

Class:Id	Reaction:5657637
_displayName	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA
_doRelease	TRUE
_timestamp	2022-09-13 18:03:44
authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
goBiologicalProcess	[GO_BiologicalProcess:17672] DNA alkylation repair
input	[GenomeEncodedEntity:5657602] 1-meA-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5656407] ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:113684] Reversal of DNA alkylation damage by two human dioxygenases. [LiteratureReference:5657644] Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3 [LiteratureReference:5656417] DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation [LiteratureReference:5657648] Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage
modified	[InstanceEdit:5657666] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5674552] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5678318] Orlic-Milacic, Marija, 2015-02-23 [InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA
output	[Complex:5657653] ALKBH3:Fe2+:ASCC1:ASCC2:ASCC3:1-meA-dsDNA [nucleoplasm] [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679928] R-HSA-5657637.3
summation	[Summation:5657626] ALKBH3 (ABH3) has a preference for binding single strand DNA...
(hasEvent)	[Pathway:112126] ALKBH3 mediated reversal of alkylation damage [Homo sapiens]
(precedingEvent)	[Reaction:112123] Oxidative demethylation of 1-meA damaged DNA By ALKBH3 [Homo sapiens]
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No pathways have been reviewed or authored by ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (5657637)