Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P49019 HCAR3
| Class:Id | ReferenceGeneProduct:56572 |
|---|---|
| _chainChangeLog | chain:1-387 added on Sat February 7 2015 |
| _displayName | UniProt:P49019 HCAR3 |
| _timestamp | 2026-02-20 22:55:16 |
| chain | chain:1-387 |
| checksum | 887BA427B6134A3F |
| comment | FUNCTION G-protein coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. Signals through the inhibitory G(i)/o family of G-proteins (PubMed:19561068, PubMed:37736747, PubMed:39427321). Acts as a negative feedback regulator of adipocyte lipolysis, helping to counterbalance prolipolytic signals during physiological or pathological elevations in beta-oxidation (PubMed:19561068). Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet (PubMed:12522134).SUBCELLULAR LOCATION Expression largely restricted to adipose tissue and spleen.MISCELLANEOUS Exists only in humans and higher primates.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Hydroxycarboxylic acid receptor 3 alternativeName: G-protein coupled receptor 109B alternativeName: fullName evidence="13"G-protein coupled receptor HM74 alternativeName: G-protein coupled receptor HM74B alternativeName: Niacin receptor 2 alternativeName: Nicotinic acid receptor 2 |
| geneName | HCAR3 GPR109B HCA3 HM74B NIACR2 |
| identifier | P49019 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | HCAR3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993661] ENSEMBL:ENSG00000255398 HCAR3 [Homo sapiens] |
| secondaryIdentifier | HCAR3_HUMAN A8K4G5 B2R830 E9PI97 Q8NGE4 |
| sequenceLength | 387 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:444718] HCAR3 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P49019 HCAR3 (56572)
