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Details on Person Defective KHK does not phosphorylate beta-D-fructose

Class:IdFailedReaction:5656459
_displayNameDefective KHK does not phosphorylate beta-D-fructose
_doReleaseTRUE
_timestamp2015-03-04 04:20:18
authored[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
catalystActivity[CatalystActivity:9631854] ketohexokinase activity of KHK mutant dimers [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5656453] D'Eustachio, Peter, 2014-12-12
disease[Disease:5656463] carbohydrate metabolic disorder
edited[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
entityFunctionalStatus[EntityFunctionalStatus:5656461] loss_of_function of KHK mutant dimers [cytosol]
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29532] Fru [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5652057] Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria
[LiteratureReference:469711] Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase)
modified[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
[InstanceEdit:5674543] D'Eustachio, Peter, 2015-02-12
[InstanceEdit:5675277] D'Eustachio, Peter, 2015-02-15
[InstanceEdit:5675813] D'Eustachio, Peter, 2015-02-16
[InstanceEdit:5675822] D'Eustachio, Peter, 2015-02-16
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective KHK does not phosphorylate beta-D-fructose
normalReaction
releaseDate2015-03-19
reviewed[InstanceEdit:5675821] Timson, David J, Tolan, Dean R, 2015-02-16
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680327] R-HSA-5656459.3
summation[Summation:5656439] Variant KHK (ketohexokinase) protein fails to catalyze the p...
(hasEvent)[Pathway:5657562] Essential fructosuria [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778468] Update Tracker - [FailedReaction:5656459] Defective KHK does not phosphorylate beta-D-fructose - v68:[addCatalystActivity]
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