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Details on Person POLK and POLZ cooperate in elongation of mispaired primer termini

Class:Id	Reaction:5655965
_displayName	POLK and POLZ cooperate in elongation of mispaired primer termini
_doRelease	TRUE
_timestamp	2015-03-04 03:54:20
authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity	[CatalystActivity:5655960] DNA-directed DNA polymerase activity of POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5655963] Orlic-Milacic, Marija, 2014-12-09
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
input	[Complex:5655912] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] [Homo sapiens] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5655838] Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ?, and Pol ? [LiteratureReference:5652156] Structural insights into the assembly of human translesion polymerase complexes [LiteratureReference:5655847] Multifaceted recognition of vertebrate Rev1 by translesion polymerases ? and ? [LiteratureReference:5655974] Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini [LiteratureReference:5655973] Role of human DNA polymerase kappa as an extender in translesion synthesis [LiteratureReference:5655978] Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene
modified	[InstanceEdit:5655983] Orlic-Milacic, Marija, 2014-12-09 [InstanceEdit:5657556] Orlic-Milacic, Marija, 2014-12-13 [InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663087] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663090] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5674553] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLK and POLZ cooperate in elongation of mispaired primer termini
output	[SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [EntityWithAccessionedSequence:3006726] REV1 [nucleoplasm] [Homo sapiens] [Complex:110279] POLZ [nucleoplasm] [Homo sapiens] [Complex:5655961] POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5655892] POLK incorporates dNMP opposite to damaged DNA base [Homo sapiens] [Reaction:5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679886] R-HSA-5655965.2
summation	[Summation:5655962] DNA polymerase kappa (POLK) can elongate mispaired primer te...
(hasEvent)	[Pathway:5655862] Translesion synthesis by POLK [Homo sapiens]
(precedingEvent)	[Reaction:5653756] TRIM25 binds monoUb:164-PCNA [Homo sapiens] [Pathway:5656169] Termination of translesion DNA synthesis [Homo sapiens]
(replacementInstances)	[_Deleted:5676178] Deletion of instance: 110324
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No pathways have been reviewed or authored by POLK and POLZ cooperate in elongation of mispaired primer termini (5655965)