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Details on Person OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer

Class:IdReaction:5655955
_displayNameOLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer
_doReleaseTRUE
_timestamp2024-04-12 19:41:44
catalystActivity[CatalystActivity:5655933] fatty acyl-[ACP] hydrolase activity of OLAH [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5655934] D'Eustachio, Peter, 2014-12-09
crossReference[DatabaseIdentifier:9865946] RHEA:30116
inferredFrom
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[Complex:5655943] decanoyl-FASN dimer [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
isChimericFALSE
literatureReference[LiteratureReference:5655942] Purification and properties of a thioesterase from lactating rat mammary gland which modifies the product specificity of fatty acid synthetase
[LiteratureReference:5655922] Interaction of rat mammary gland thioesterase II with fatty acid synthetase is dependent on the presence of acyl chains on the synthetase
[LiteratureReference:5656424] The fatty acids of human milk from mothers on diets taken ad libitum
[LiteratureReference:5656418] Triglyceride structure of human milk fat
modified[InstanceEdit:5656423] D'Eustachio, Peter, 2014-12-12
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
[InstanceEdit:5668968] D'Eustachio, Peter, 2015-01-29
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
[InstanceEdit:9907565] D'Eustachio, Peter, 2024-04-12
[InstanceEdit:9907580] D'Eustachio, Peter, 2024-04-12
nameOLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer
decanoyl-(ACP) + H2O => decanoate + H(+) + holo-(ACP)
decanoyl-FASN dimer + 2 H2O => 2 decanoate + FASN dimer
output[SimpleEntity:879620] DECA [cytosol]
[SimpleEntity:879620] DECA [cytosol]
[Complex:77380] FASN dimer [cytosol] [Homo sapiens]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2014-09-30
reviewed[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
[InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680259] R-HSA-5655955.4
structureModified[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
summation[Summation:5655952] OLAH, a monomeric cytosolic thiolase, catalyzes the hydrolys...
(hasEvent)[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9910981] Update Tracker - [Reaction:5655955] OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer - v89:[addOutput]
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