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Details on Person POLK incorporates dNMP opposite to damaged DNA base

Class:IdReaction:5655892
_displayNamePOLK incorporates dNMP opposite to damaged DNA base
_doReleaseTRUE
_timestamp2015-03-04 03:49:00
authored[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity[CatalystActivity:5655907] DNA-directed DNA polymerase activity of POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5655914] Orlic-Milacic, Marija, 2014-12-09
edited[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
input[Complex:5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] [Homo sapiens]
[SimpleEntity:30555] dNTP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:5655901] Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides
[LiteratureReference:5655880] A role for DNA polymerase ? in promoting replication through oxidative DNA lesion, thymine glycol, in human cells
[LiteratureReference:5655893] Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells
[LiteratureReference:5655887] Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion
[LiteratureReference:5655883] Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro
[LiteratureReference:5655894] Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa
[LiteratureReference:5655878] Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase ? elucidates error-free bypass of a bulky DNA lesion
[LiteratureReference:5655868] Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases
[LiteratureReference:5655910] Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa
[LiteratureReference:5655913] Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions
[LiteratureReference:5656288] Detection of smoking-related covalent DNA adducts in human placenta
modified[InstanceEdit:5656296] Orlic-Milacic, Marija, 2014-12-11
[InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5663087] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5663090] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5674553] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePOLK incorporates dNMP opposite to damaged DNA base
output[SimpleEntity:113541] PPi [nucleoplasm]
[Complex:5655912] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-03-19
reviewed[InstanceEdit:5663080] Borowiec, James, 2015-01-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5679787] R-HSA-5655892.2
summation[Summation:5655866] DNA polymerase kappa (POLK) is the most efficient in incorpo...
(hasEvent)[Pathway:5655862] Translesion synthesis by POLK [Homo sapiens]
(precedingEvent)[Reaction:5655965] POLK and POLZ cooperate in elongation of mispaired primer termini [Homo sapiens]
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No pathways have been reviewed or authored by POLK incorporates dNMP opposite to damaged DNA base (5655892)
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