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Details on Person DNA polymerase kappa (POLK) is the most efficient in incorpo...

Class:IdSummation:5655866
_displayNameDNA polymerase kappa (POLK) is the most efficient in incorpo...
_timestamp2014-12-11 17:57:26
created[InstanceEdit:5655914] Orlic-Milacic, Marija, 2014-12-09
modified[InstanceEdit:5656199] Orlic-Milacic, Marija, 2014-12-11
[InstanceEdit:5656296] Orlic-Milacic, Marija, 2014-12-11
textDNA polymerase kappa (POLK) is the most efficient in incorporation of nucleotides opposite to oxidation derivatives of DNA bases, such as thymine glycol (Tg) and 8-oxoguanine (OGUA). POLK preferentially incorporates dAMP opposite both Tg and OGUA, resulting in error-free translesion DNA synthesis (TLS) across Tg lesions (Fischhaber et al. 2002, Yoon et al. 2010, Yoon et al. 2014) and frequent G:C -> T:A transversions at OGUA lesions (Zhang et al. 2000, Vasquez-Del Carpio et al. 2009). POLK is also efficient in TLS across bulky DNA adducts, such as the smoking-related benzo(a)pyrene diol epoxide guanine adduct (BPDE-G) (Everson et al. 1986), and it correctly incorporates dCMP opposite to BPDE-G (Zhang et al. 2000, Avkin et al. 2004, Lior-Hoffmann et al. 2012, Christov et al. 2012). POLK is incapable of TLS across thymine-thymine dimers (Ohashi et al. 2000) and shows a very low efficiency in TLS across AP sites, where it mainly causes single base deletions (-1 frameshifts) through template-primer misalignment (Ohashi et al. 2000, Wolfle et al. 2003).
(summation)[Reaction:5655892] POLK incorporates dNMP opposite to damaged DNA base [Homo sapiens]
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