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Details on Person POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template

Class:Id	Reaction:5655835
_displayName	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
_doRelease	TRUE
_timestamp	2017-04-25 20:48:38
authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5655860] Orlic-Milacic, Marija, 2014-12-09
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
input	[Complex:5655492] POLK:Mg2+,Mn2+ [nucleoplasm] [Homo sapiens] [Complex:5655850] MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3006726] REV1 [nucleoplasm] [Homo sapiens] [Complex:110279] POLZ [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5655844] Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function [LiteratureReference:5655838] Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ?, and Pol ? [LiteratureReference:5652156] Structural insights into the assembly of human translesion polymerase complexes [LiteratureReference:5655847] Multifaceted recognition of vertebrate Rev1 by translesion polymerases ? and ? [LiteratureReference:5655488] Bypass of N�-ethylguanine by human DNA polymerase ? [LiteratureReference:5655830] Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA [LiteratureReference:5655970] Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest
modified	[InstanceEdit:5655983] Orlic-Milacic, Marija, 2014-12-09 [InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663087] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663090] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5674553] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8986377] Orlic-Milacic, Marija, 2017-04-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
output	[Complex:5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA [Homo sapiens] [Reaction:5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679713] R-HSA-5655835.3
summation	[Summation:5655856] DNA polymerase kappa (POLK) forms a quaternary complex with ...
(hasEvent)	[Pathway:5655862] Translesion synthesis by POLK [Homo sapiens]
(precedingEvent)	[Reaction:5655892] POLK incorporates dNMP opposite to damaged DNA base [Homo sapiens]
(replacementInstances)	[_Deleted:5676179] Deletion of instance: 110321
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No pathways have been reviewed or authored by POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (5655835)