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Details on Person UV radiation, through an unknown mechanism, triggers USP1 au...
| Class:Id | Summation:5655472 |
|---|---|
| _displayName | UV radiation, through an unknown mechanism, triggers USP1 au... |
| _timestamp | 2017-11-13 16:39:41 |
| created | [InstanceEdit:5655468] Orlic-Milacic, Marija, 2014-12-05 |
| modified | [InstanceEdit:5656185] Orlic-Milacic, Marija, 2014-12-11 [InstanceEdit:5663038] Orlic-Milacic, Marija, 2015-01-14 [InstanceEdit:9028891] Orlic-Milacic, Marija, 2017-11-13 |
| text | UV radiation, through an unknown mechanism, triggers USP1 autocleavage immediately after a conserved Gly-Gly motif. The products of USP1 autocleavage are targeted for proteasome-mediated degradation, thus preventing the activity of USP1:WDR48 (USP1:UAF1) deubiquitinase complex and allowing for monoubiquitinated PCNA to accumulate and stimulate translesion DNA synthesis (TLS) (Huang et al. 2006). |
| (summation) | [Reaction:5655483] USP1 autocleavage [Homo sapiens] |
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No pathways have been reviewed or authored by UV radiation, through an unknown mechanism, triggers USP1 au... (5655472)
