Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Mammalian target of rapamycin (mTOR) is a highly conserved s...
| Class:Id | Summation:5655425 |
|---|---|
| _displayName | Mammalian target of rapamycin (mTOR) is a highly conserved s... |
| _timestamp | 2026-02-19 16:08:37 |
| created | [InstanceEdit:5655428] Jupe, Steve, 2014-12-05 |
| literatureReference | [LiteratureReference:5655429] mTOR: from growth signal integration to cancer, diabetes and ageing [LiteratureReference:5655434] mTOR signaling in growth control and disease [LiteratureReference:9982836] Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship [LiteratureReference:9982840] The central moTOR of metabolism |
| modified | [InstanceEdit:9982847] Orlic-Milacic, Marija, 2026-02-19 |
| text | Mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Control of mTOR activity is critical for the cell since its dysregulation leads to cancer, metabolic disease, and diabetes (Laplante & Sabatini 2012). In cells, mTOR exists as two structurally distinct complexes termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), each one with specificity for different sets of effectors (reviewed in Jhanwar-Uniyal et al. 2019). mTORC1 couples energy and nutrient abundance to cell growth and proliferation by balancing anabolic (protein synthesis and nutrient storage) and catabolic (autophagy and utilization of energy stores) processes. mTORC2 is responsive to growth factor signaling (reviewed in Jhanwar-Uniyal et al. 2019). mTORC1 and mTORC2 cross-talk through AKT and S6K (reviewed in Jhanwar-Uniyal et al. 2019). Rapamycin, the inhibitor of mTOR, inhibits only mTORC1, as the RICTOR subunit of mTORC2 masks the rapamycin-interacting domain of MTOR in mTORC2 (reviewed in Simcox and Lamming 2023). |
| (summation) | [Pathway:165159] MTOR signalling [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Mammalian target of rapamycin (mTOR) is a highly conserved s... (5655425)
