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Details on Person Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Class:IdReaction:5655347
_displayNameActivated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
_doReleaseTRUE
_timestamp2015-03-04 03:46:57
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity[CatalystActivity:5655287] guanyl-nucleotide exchange factor activity of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease[Disease:1500689] cancer
[Disease:2032940] bone development disease
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5655317] gain_of_function of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
input[SimpleEntity:29438] GTP [cytosol]
[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:2011995] FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells
[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
[LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
[LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
modified[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
normalReaction
output[SimpleEntity:29420] GDP [cytosol]
[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens]
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5679747] R-HSA-5655347.2
summation[Summation:1982087] Activation of Erk1/2 downstream of FGFR mutants suggests tha...
(hasEvent)[Pathway:5655291] Signaling by FGFR4 in disease [Homo sapiens]
(replacementInstances)[_Deleted:5655673] Deletion of instance: 1982085
(updatedInstance)[_UpdateTracker:9775325] Update Tracker - [Reaction:5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - v79:[modifyText]
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