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Details on Person Activated FGFR2 mutants bind FRS2

Class:Id	Reaction:5655339
_displayName	Activated FGFR2 mutants bind FRS2
_doRelease	TRUE
_timestamp	2015-03-04 03:49:17
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655334] gain_of_function of Activated FGFR2 mutants [plasma membrane]
input	[DefinedSet:5654747] Activated FGFR2 mutants [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:170963] FRS2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling [LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR2 mutants bind FRS2
normalReaction	[Reaction:5654399] Activated FGFR2 binds FRS2 [Homo sapiens]
output	[Complex:5655257] Activated FGFR2 mutants:FRS2 [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679795] R-HSA-5655339.2
summation	[Summation:1982075] After activation, FGFR mutants are presumed to recruit FRS2 ...
(hasEvent)	[Pathway:5655253] Signaling by FGFR2 in disease [Homo sapiens]
(replacementInstances)	[_Deleted:5655672] Deletion of instance: 1982073
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No pathways have been reviewed or authored by Activated FGFR2 mutants bind FRS2 (5655339)