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Details on Person Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1

Class:IdReaction:5655320
_displayNameActivated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
_doReleaseTRUE
_timestamp2018-12-12 17:34:45
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease[Disease:2032940] bone development disease
[Disease:1500689] cancer
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:9632015] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane]
input[Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] [Homo sapiens]
[Complex:179864] GRB2:GAB1:PIK3R1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
[LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
modified[InstanceEdit:5655508] Rothfels, Karen, 2014-12-05
[InstanceEdit:5655655] Rothfels, Karen, 2014-12-08
[InstanceEdit:9632016] Rothfels, Karen, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
normalReaction
output[Complex:5655330] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680316] R-HSA-5655320.3
summation[Summation:1986644] FGFR1-amplified cells derived from lung cancer patients show...
(hasEvent)[Pathway:5655253] Signaling by FGFR2 in disease [Homo sapiens]
(replacementInstances)[_Deleted:5655675] Deletion of instance: 1986643
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No pathways have been reviewed or authored by Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (5655320)
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