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Details on Person Activated FGFR2 mutants phosphorylate PLCG1

Class:Id	Reaction:5655301
_displayName	Activated FGFR2 mutants phosphorylate PLCG1
_doRelease	TRUE
_timestamp	2015-03-04 04:20:59
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:5655250] protein tyrosine kinase activity of Activated FGFR2 mutants:PLCG1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease	[Disease:2032940] bone development disease [Disease:1500689] cancer
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655246] gain_of_function of Activated FGFR2 mutants:PLCG1 [plasma membrane]
input	[Complex:5655346] Activated FGFR2 mutants:PLCG1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR2 mutants phosphorylate PLCG1
normalReaction	[Reaction:5654147] Activated FGFR2 phosphorylates PLCG1 [Homo sapiens]
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:5654745] Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680337] R-HSA-5655301.2
summation	[Summation:2077386] By analogy with the wild-type pathway, PLC-gamma is presumed...
(hasEvent)	[Pathway:5655253] Signaling by FGFR2 in disease [Homo sapiens]
(precedingEvent)	[Reaction:5654748] p-4Y-PLCG1 dissociates from activated FGFR2 mutants [Homo sapiens]
(replacementInstances)	[_Deleted:5655676] Deletion of instance: 2077384
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No pathways have been reviewed or authored by Activated FGFR2 mutants phosphorylate PLCG1 (5655301)