Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3

Class:Id	Reaction:5655289
_displayName	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
_doRelease	TRUE
_timestamp	2021-09-15 23:40:38
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:5655273] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655286] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
modified	[InstanceEdit:9753844] Rothfels, Karen, 2021-09-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
normalReaction	[Reaction:5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15 [InstanceEdit:8853855] Grose, Richard P, 2016-01-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679939] R-HSA-5655289.3
summation	[Summation:8853071] Once recruited to the activated receptor, PI3K phosphorylate...
(hasEvent)	[Pathway:5655332] Signaling by FGFR3 in disease [Homo sapiens]
(replacementInstances)	[_Deleted:5655677] Deletion of instance: 1986647 [_Deleted:9768277] Deletion of instance: 8853323
(updatedInstance)	[_UpdateTracker:9775323] Update Tracker - [Reaction:5655289] Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 - v79:[add_removeSummation]
[Change default viewing format]

No pathways have been reviewed or authored by Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (5655289)