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Details on Person Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA

Class:IdReaction:5655263
_displayNameActivated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
_doReleaseTRUE
_timestamp2015-03-04 04:22:06
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease[Disease:1500689] cancer
[Disease:2032940] bone development disease
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5655349] gain_of_function of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
input[Complex:5655218] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:74787] PIK3CA [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
[LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
modified[InstanceEdit:5655652] Rothfels, Karen, 2014-12-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
normalReaction
output[Complex:5655217] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680363] R-HSA-5655263.2
summation[Summation:2085647] Activation of the PI3K pathway has been demonstrated downstr...
(hasEvent)[Pathway:5655302] Signaling by FGFR1 in disease [Homo sapiens]
(precedingEvent)[Reaction:5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(replacementInstances)[_Deleted:5655666] Deletion of instance: 1986645
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